Monitor for adverse effects of sensitive CYP3A4 substrates if coadministered with mavorixafor (a weak CYP3A4 inhibitor). mavorixafor will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metolazonetadalafil increases effects of metolazone by pharmacodynamic synergism.
| Country | Legal Status | Prescription Required | Notes |
|---|---|---|---|
| USA | Prescription-only | Yes | Approved for ED and BPH |
| UK | Prescription-only | Yes | Controlled medication |
| Canada | Prescription-only | Yes | Available via pharmacy |
| Australia | Prescription-only | Yes | Schedule 4 drug |
| India | Prescription required | Yes | Widely available |
tadalafil increases effects of metolazone by pharmacodynamic synergism.
Dosing & Uses
Combination may increase risk of orthostatic hypotension, tachycardia, dizziness and headache. etravirineetravirine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. etravirine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fedratinibfedratinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Adjust dose of drugs that are CYP3A4 substrates as necessary.
Length of treatment
fedratinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. felodipinetadalafil increases effects of felodipine by pharmacodynamic synergism. tadalafil increases effects of felodipine by pharmacodynamic synergism. fluconazolefluconazole will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fluconazole will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
The Bottom Line
fluvoxaminefluvoxamine will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fluvoxamine will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fosaprepitantfosaprepitant will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fosaprepitant will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fosinopriltadalafil increases effects of fosinopril by pharmacodynamic synergism. metoprololtadalafil increases effects of metoprolol by pharmacodynamic synergism. tadalafil increases effects of metoprolol by pharmacodynamic synergism.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Cialis Generic | 60mg | 30 + 2 Pills | 85.33€ 81.27€ | |
| Cialis Generic | 20mg | 120 + 8 Pills | 188.15€ 179.19€ | |
| Cialis Generic | 40mg | 270 + 10 Pills | 382.19€ 363.99€ | |
| Cialis Generic | 40mg | 180 + 10 Pills | 277.29€ 264.09€ | |
| Cialis Generic | 60mg | 120 + 8 Pills | 240.18€ 228.74€ | |
| Cialis Generic | 5mg | 60 + 4 Pills | 86.02€ 81.92€ | |
| Tadalista Super Active | 20mg | 270 + 30 Pills | 661.49€ 629.99€ | |
| Cialis Generic | 10mg | 10 Pills | 31.41€ 29.91€ | |
| Cialis Generic | 10mg | 30 + 4 Pills | 63.32€ 60.30€ | |
| Cialis Generic | 2.5mg | 180 + 10 Pills | 154.86€ 147.49€ | |
| Cialis Generic | 2.5mg | 270 + 10 Pills | 199.64€ 190.13€ | |
| Cialis Generic | 40mg | 30 + 4 Pills | 74.97€ 71.40€ | |
| Cialis Generic | 10mg | 360 + 10 Pills | 388.49€ 369.99€ | |
| Cialis Generic | 20mg | 60 + 6 Pills | 117.76€ 112.15€ | |
| Cialis Generic | 10mg | 20 Pills | 48.23€ 45.93€ | |
| Cialis Generic | 40mg | 10 Pills | 37.79€ 35.99€ | |
| Tadalista Super Active | 20mg | 20 + 4 Pills | 92.35€ 87.95€ |
metronidazolemetronidazole will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metronidazole will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. mifepristonemifepristone will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. mifepristone will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. minoxidiltadalafil increases effects of minoxidil by pharmacodynamic synergism. tadalafil increases effects of minoxidil by pharmacodynamic synergism. mitotanemitotane decreases levels of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments.
| Parameter | Value | Description |
|---|---|---|
| Absorption Rate | Rapid | Peaks in about 2 hours |
| Bioavailability | 80% | Percentage absorbed into bloodstream |
| Half-life | 17.5 hours | How long the drug stays active |
| Metabolism | Liver via CYP3A4 | Hepatic processing |
| Excretion | Feces and urine | Mainly via feces |
mitotane decreases levels of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nadololtadalafil increases effects of nadolol by pharmacodynamic synergism. tadalafil increases effects of nadolol by pharmacodynamic synergism. nafcillinnafcillin will decrease the level or effect of tadalafil by affecting hepatic/intestinal sublingual tadalafil enzyme CYP3A4 metabolism. nafcillin will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
- Cost-saving tip: ask for a 90-day supply if on daily therapy.
- Some insurance plans have tiered formularies affecting copay.
- Manufacturer of Cialis (Eli Lilly) may offer savings programs.
- International nonproprietary name (INN) is tadalafil.
- Patent expirations allowed for generic market entry.
- Always verify pharmacy accreditation before purchasing online.
nebivololtadalafil increases effects of nebivolol by pharmacodynamic synergism. tadalafil increases effects of nebivolol by pharmacodynamic synergism. nefazodonenefazodone will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nefazodone will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nevirapinenevirapine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nevirapine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
17.9 Alcohol
labetaloltadalafil increases effects of labetalol by pharmacodynamic synergism. tadalafil increases effects of labetalol by pharmacodynamic synergism. lapatiniblapatinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lapatinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. letermovirletermovir increases levels of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study
letermovir increases levels of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lisinopriltadalafil increases effects of lisinopril by pharmacodynamic synergism. tadalafil increases effects of lisinopril by pharmacodynamic synergism. losartantadalafil increases effects of losartan by pharmacodynamic synergism. tadalafil increases effects of losartan by pharmacodynamic synergism.
2.3 Outcome measures
lumefantrinelumefantrine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lumefantrine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. marijuanamarijuana will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. marijuana will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. mavorixaformavorixafor will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nifedipinenifedipine will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
- May cause dizziness; avoid driving until you know its effects.
- Can cause nasal congestion, flushing, or muscle aches.
- Serious cardiovascular events are possible during sexual activity.
- Men with pre-existing heart conditions should use with caution.
- Seek emergency help for chest pain, dizziness, or nausea during sex.
- Inform all healthcare providers you are taking tadalafil.
Risk of hypotension.tadalafil increases effects of nifedipine by pharmacodynamic synergism. nifedipine will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nilotinibnilotinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nilotinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
| Condition | Caution Level | Explanation |
|---|---|---|
| Use with Nitrates | Contraindicated | Risk of severe hypotension |
| Severe Hepatic Impairment | Caution | Altered metabolism, dose adjustment needed |
| Severe Renal Impairment | Caution | Increased drug exposure risk |
| Retinitis Pigmentosa | Caution | Potential for vision-related side effects |
| Recent Stroke or Heart Attack | Caution | Cardiovascular risks |
nimodipinetadalafil increases effects of nimodipine by pharmacodynamic synergism. tadalafil increases effects of nimodipine by pharmacodynamic synergism. nisoldipinetadalafil increases effects of nisoldipine by pharmacodynamic synergism. tadalafil increases effects of nisoldipine by pharmacodynamic synergism.
- Not a cure for erectile dysfunction; treats symptoms.
- Psychological factors can contribute to ED; therapy may help.
- Can be used in combination with lifestyle changes (diet, exercise).
- Quitting smoking can improve overall vascular health and ED.
- Managing stress and anxiety can enhance treatment effectiveness.
- Open communication with your partner is encouraged.
olmesartantadalafil increases effects of olmesartan by pharmacodynamic synergism.
- Onset of action for on-demand use is typically 30-45 minutes.
- Maximum plasma concentration is reached within 2 hours.
- High-fat meal can delay time to maximum concentration.
- The 36-hour window does not mean an erection lasts that long.
- It means the ability to get an erection when stimulated is possible.
- Daily dosing leads to steady-state concentration in about 5 days.
tadalafil increases effects of olmesartan by pharmacodynamic synergism. pazopanibpazopanib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Why is this medication prescribed?
imatinibimatinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. imatinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. indapamidetadalafil increases effects of indapamide by pharmacodynamic synergism. tadalafil increases effects of indapamide by pharmacodynamic synergism. irbesartantadalafil increases effects of irbesartan by pharmacodynamic synergism.
Side effects and safety warnings for tadalafil
tadalafil increases effects of irbesartan by pharmacodynamic synergism. isoniazidisoniazid will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. isoniazid will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. isradipinetadalafil increases effects of isradipine by pharmacodynamic synergism. tadalafil increases erectile dysfunction pills tadalafil effects of isradipine by pharmacodynamic synergism.
Patient resources
istradefyllineistradefylline will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect was not observed with istradefylline 20 mg/day. Consider dose reduction of sensitive CYP3A4 substrates. istradefylline will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. pazopanib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
12.3 Pharmacokinetics
tadalafil increases effects of fosinopril by pharmacodynamic synergism. fosphenytoinfosphenytoin will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fosphenytoin will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. furosemidetadalafil increases effects of furosemide by pharmacodynamic synergism. tadalafil increases effects of furosemide by pharmacodynamic synergism.
2.1 Patients
grapefruitgrapefruit will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. grapefruit will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. griseofulvingriseofulvin will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. griseofulvin will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. guanfacinetadalafil increases effects of guanfacine by pharmacodynamic synergism.
Is taking a higher dose of tadalafil more effective?
tadalafil increases effects of guanfacine by pharmacodynamic synergism. hydralazinetadalafil increases effects of hydralazine by pharmacodynamic synergism. tadalafil increases effects of hydralazine by pharmacodynamic synergism. hydrochlorothiazidetadalafil increases effects of hydrochlorothiazide by pharmacodynamic synergism. tadalafil increases effects of hydrochlorothiazide by pharmacodynamic synergism. pentobarbitalpentobarbital will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. pentobarbital will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.