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Other > medicine for erectile dysfunction


  • Erectile dysfunction isn’t all or nothing
  • Can Supplements Help Erectile Dysfunction?
  • How and when to take the medications
  • Erectile Dysfunction Injections

Erectile Dysfunction: AUA Guideline (2018)

Additional treatments that may be used to treat ED include those listed below. Penis pump: Also called a vacuum erection device (VED) or external vacuum device, this is a sealed chamber (such as a plastic tube) placed over the penis.

Erectile dysfunction isn’t all or nothing

Regular exercise also helps by reducing stress, assisting with weight management and increasing blood flow. High blood pressure, high cholesterol and diabetes are the three most common conditions that affect erectile function. Controlling these illnesses is vital to maintaining penile health. Reducing stress, avoiding red meat and processed foods, eating a heart-healthy diet and limiting excess sugar, caffeine and dairy products may help men manage these conditions. Both tobacco smoking and smokeless tobacco products may cause blood vessels that supply blood to the penis to narrow or stiffen, making it more difficult to attain and maintain erections.

See, Play and Learn

Increased fat in the belly region increases activity of an enzyme called aromatase that converts the male sex hormone testosterone to estrogen. Since testosterone helps control male sex drive, reduced levels may lead to ED. A group of compounds called xenobiotics may contribute to ED by lowering testosterone levels. These include BPA (bisphenol A), phthalates and organophosphates, which may be found in items such as plastics, lubricants, coatings, pesticides and herbicides. Thoughts and emotions impact the body and may alter men’s sexual functioning.

Be physically active

Treatments such as cognitive behavioral therapy, guided imagery and clinical hypnosis may be used to help address emotional issues that are driving ED. Mental health professionals assist men by addressing performance anxiety and helping couples incorporate new strategies into their sexual relationships. Sometimes, drugs that are prescribed for cancer, depression, Parkinson’s disease, high blood pressure, heartburn or other conditions may contribute to ED. Men experiencing ED should review their medications with their doctor, who may suggest trying out different ones that may be less likely to trigger ED. Because stopping a drug may lead to life-threatening health consequences, men should always work with their doctor when changing medications. It contains a pump to pull air out of the chamber, creating a vacuum that allows blood to flow into the penis. After the penis is erect, a restrictive band is placed at its base to trap the blood. This band is left in place for up to 30 minutes. The device is safe and cost-effective and works well in most cases, though some men report dissatisfaction.

  • Regular check-ups help monitor underlying health issues causing ED.
  • Conditions like diabetes and hypertension impact erectile function.
  • Early diagnosis improves treatment outcomes.
  • Medication adjustments may be necessary over time.
  • Open communication with a healthcare provider is key.
  • Proactive health management can prevent worsening of ED.

Practice and patience are required for consistent results, and VEDs may cause (mostly painless) bruising on the penis that takes a few days to heal.

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In addition, the penis tends to be cool to the touch during performance, as there is no active blood flow while the restrictive band is in place. VEDs are usually prescribed by a doctor, although some are available over the counter. Testosterone therapy (testosterone supplementation): Since low testosterone levels may reduce men’s sexual desire and lead to erection issues, this hormone is sometimes given to patients with ED who have hormonal imbalances. But it is not typically considered an appropriate treatment for ED, and it is not usually prescribed for patients with certain types of cancer, such as untreated or recurrent prostate cancer.

Drug Type Mechanism of Action Target Enzyme/Pathway Typical Use Cases
PDE5 Inhibitors Inhibit phosphodiesterase type 5 enzyme PDE5 enzyme Relaxation of penile arteries
Testosterone Replacement Increase testosterone levels Hormonal pathway Hormonal deficiency cases
Vasodilators Directly relax smooth muscle Nitric oxide pathway Severe cases of ED
Melanocortin Agonists Stimulate melanocortin receptors Central nervous system Experimental, limited availability

Other potential side effects of testosterone supplementation include issues with urinating and high red blood cell counts. Other external penile prostheses: Constriction rings are placed at the base of the penis to help stop blood from leaving the penis during sex, similar to the band used with a VED.

Can Supplements Help Erectile Dysfunction?

These include medications, intraurethral suppositories, penile injections, and a penile implant. Read more about these treatments below and talk with your urologist to find the right impotence treatment for you. This page was reviewed under our medical and editorial policy by Humberto Villarreal, M.D., urologic surgeon and assistant clinical professor, Division of Urology and Urologic Oncology, Department of Surgery, City of Hope® Cancer Center Duarte. Erectile dysfunction (ED) affects as many as 30 million men in the United States. ED treatment recommendations address the underlying cause of the condition in each patient, such as certain cancer treatments or health issues that may make it difficult to maintain an erection.

Getting Treatments for Erectile Dysfunction

A patient’s care team also considers his individual health and the severity of his ED when putting together an ED treatment plan. The risks and benefits of treatment options will be reviewed with each patient. Nearly everyone who undergoes treatment for ED has successful outcomes using one or a combination of ED therapies, from lifestyle changes to medications and surgery. Below is a detailed breakdown of the various treatment options, including why and when they may be used. For some men, lifestyle changes may be enough to treat ED, because healthy habits play a key role in getting and maintaining erections.

The Connection Between Diabetes and Erectile Dysfunction

Below are seven lifestyle changes used to help treat ED. Exercising and maintaining behaviors that positively impact wellness may help combat ED. This includes eating a healthy diet containing foods such as fruits, vegetables, nuts, fiber, green tea and flaxseed. Dietary supplements such as L-arginine, OPCs (found in grape seeds and pine bark) and red ginseng may also be beneficial for improving ED. In particular, the Mediterranean diet has been demonstrated to be the most balanced in promoting wellness and sexual health. They are beneficial for men who achieve erections but do not tend to maintain them. During intercourse, men may also use a penile splint, which is a device that supports and holds the penis in place and contains a quick-release mechanism for fast removal.

  • ED is often a sign of underlying health problems.
  • Cardiovascular health directly affects erectile function.
  • Managing chronic illnesses can prevent or improve ED.
  • Proactive lifestyle and medical management are essential.
  • Emotional well-being is also a key factor.
  • Addressing root causes offers the best long-term solution.

Side effects of these devices may include bruising, rupture of blood vessels and aggravation of preexisting conditions, such as priapism (prolonged erection) and Peyronie’s disease (penile curvature).

  • Sildenafil (Viagra): A popular PDE5 inhibitor to treat erectile dysfunction.
  • Tadalafil (Cialis): Offers longer-lasting effects for up to 36 hours.
  • Vardenafil (Levitra): Acts quickly and lasts several hours.
  • Stendra (Avanafil): Provides rapid onset of action within 15 minutes.
  • Alprostadil (injection): Penetrates directly into the penis to induce an erection.
  • Erectile dysfunction patches: Topical patches delivering medication for quicker absorption.

Definition & facts for erectile dysfunction, July 2017. How cancer can affect erections, February 5, 2020. U.S.

How and when to take the medications

When lifestyle changes are not enough to correct ED, a doctor may prescribe the erectile dysfunction medications like those listed below. Oral medications: Oral medications used to treat ED include the pills Viagra® (sildenafil), Cialis® (tadalafil), Levitra® or Staxyn® (vardenafil) and Stendra® (avanafil). These medications should never be taken with nitrate drugs for chest pain, and they should be taken under close supervision by a medical professional in any patient taking alpha blockers for high blood pressure or an enlarged prostate. Penile injection therapy: Some medications may safely be injected directly cenforce 100 soft into the penis. These medications include edex® (alprostadil), Pavacot® (papaverine) and OraVerse® or Regitine® (phentolamine).

Medical treatments:

A compounded mixture of the previously mentioned medications may also be prescribed in order to maximize results while reducing side effects. The first dose of the injection therapy is usually administered under the supervision of a health care provider. While men may be apprehensive about giving themselves a penile injection, it is considered one of the most reliable ED treatments and may be an appropriate option when oral medication does not work. Urethral pellet: Also known as MUSE®, this tiny pellet is placed into the urethra to dissolve and be absorbed into the erectile tissue. Though it may be easier to administer than an injection, MUSE is not always as successful.

Hormone replacement therapy

Side effects of ED medications may include priapism (a prolonged erection) and vision or hearing loss. Men who experience loss of sight or hearing or who have an erection lasting more than four hours should contact their doctor right away. ED medications may not work for everyone and may be less successful after certain procedures, such as prostate surgery. This is because some medications stimulate the nerves, which may be damaged after an operation. When both lifestyle changes and Viagra, Cialis and other medications fail, penile implant surgery may be an appropriate option. Department of Veterans Affairs, Whole Health Library.

Erectile Dysfunction Injections

Penile implants (penile prosthesis) are safe and provide spontaneous and reliable results along with a sustained quality of life for men who choose this ED treatment option. There are two types of implants: those that inflate and deflate, and those that are always firm (semirigid). The implant is placed through a small incision within the tunica albuginea (fibrous tissues that stretch during erection), which allows the penis to become rigid for intercourse. The operation to implant the prosthesis may take place in an outpatient clinic or hospital. Most men stay overnight in the hospital to ensure proper follow-up care.

Can ED medications cause permanent damage or long-term side effects?

Pain medication may be prescribed, and patients are typically told to avoid heavy lifting for seven to 14 days after the surgery. The potential risks of penile prosthesis include infection, bleeding and pain. In addition, since the device is mechanical, it may break down over time. However, with newer models and advanced surgical techniques, the rate of mechanical failure and infection has been reduced. A penile implant device may be used four to six weeks after the operation.

Table 4. Additional Testing in the Workup of Erectile Dysfunction

Men must use it to get an erection after surgery, and, once an implant is placed, no other form of treatment will work. In addition to penile prosthesis implantation, artery reconstruction surgery is another procedure sometimes used to treat ED. Artery damage is a potential underlying cause of ED and may occur for a number of reasons, including as a side effect of radiation therapy. The doctor may recommend artery reconstruction surgery for younger men with ED who do not have vascular disease or sinusoidal obstruction syndrome (veno-occlusive disease), a condition of the liver. During the procedure, arteries are repaired and rebuilt to remove blockages that impede blood flow to the penis. U.S.

Treatment Option Description Effectiveness Benefits Limitations
Vacuum Erection Devices External pump creates vacuum to induce erection Moderate No drugs required, reversible Discomfort, mechanical failure
Penile Implants Surgical insertion of device High Permanent solution Surgery risks, costs
Psychosexual Therapy Counseling for psychological issues Varies Addresses underlying causes Time-consuming, requires cooperation
Lifestyle Changes Exercise, diet, quitting smoking Moderate Improves overall health Requires consistency

Department of Health and Human Services, My Health Finder.

Area of Research Description Promising Developments Challenges
Gene Therapy Targeting genetic causes of ED Experimental treatments Delivery and safety concerns
Stem Cell Therapy Regenerating erectile tissue Early clinical trials Efficacy and long-term effects
NO-Donors and Nitric Oxide Modulators Enhancing natural nitric oxide production New drug candidates Side effects and regulation
Pharmacogenomics Personalized medicine based on genetics Custom drug development Complexity of genetic profiling
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