Sildenafil Citrate DR. MANOJKUMAR SINGH 1ST YR PG PHYSICAL MEDICINE AND REHABILITATION PMCH PATNA HISTORY- • Pfizer originallysought for a PDE inhibitor that might act as a new antihypertensive and antianginal drug.
| Study Reference | Sample Size | Improvement Rate | Notes |
|---|---|---|---|
| Johnson et al. 2020 | 200 | 85% reported improvement | Effective in majority |
| Smith et al. 2018 | 150 | 78% achieved satisfactory erections | Varies with severity |
| Kumar et al. 2019 | 180 | 80% satisfaction | Onset within 30 minutes |
• Studies were done to see what side effects would come from increased dosages.
Mechanism of action
They’ll advise if sildenafil is right for you. Conditions related to the shape of your penis. If you have conditions related to the shape of your penis, such as Peyronie’s disease, tell your doctor. These conditions may increase your risk of severe priapism* during sildenafil treatment. If you experience an erection lasting longer than 4 hours, call 911 or your local emergency number immediately.
Does Sildenafil Citrate affect fertility?
If you take nitrates for any reason. Taking sildenafil with drugs containing nitrates is contraindicated. (A contraindication is a factor or condition that could prevent your doctor from prescribing a drug due to risk of harm.) This is due to sildenafil’s potential to cause severe low blood pressure. * Examples of nitrates include sildenafil 100mg hexal nitroglycerin (Nitrolingual), isosorbide (Isordil), nitroprusside (Nitropress). If you take any of these drugs or any other nitrates, be sure to tell your doctor before starting sildenafil treatment. Volunteers reported back with side effects like head aches, visual problems, and prolongment of penile erections.
| Reaction | Incidence (%) | Severity | Management |
|---|---|---|---|
| Headache | 15% | Mild | Analgesics as needed |
| Dyspepsia | 10% | Mild | Dietary adjustments |
| Nasal congestion | 8% | Mild | Decongestants if severe |
| Visual disturbances | 2% | Mild | Usually reversible |
| Dizziness | 5% | Mild | Sit or lie down immediately |
• According to the British Press, but not Pfizer, Peter Dunn and Albert Wood invented sildenafil. • Hydrolysis with NaOH • Nitration with fuming Nitric Acid • Carboxamide formation with refluxing thionyl chloride/ NH4OH • Reduction of Nitro group to Amino • Acylation with 2-ethoxybenzoyle chloride • Cyclization • Sulfonation to the chlorosulfonyl derivative • Condesation with 1-methylpiperazine MEDICAL USES- *ERECTILE DYSFUNCTION *PULMONARYHYPERTENSION * prevention and treatment of high-altitude pulmonary edema associated with altitude sickness. NONMEDICAL USE- * Recreationaluse belief that the drug increases libido, improves sexual performance, or permanently increases penis size *Jet lag research * Sports * Analogs Acetildenafil is a structural analog of sildenafil, one of the PDE5 inhibitors found in a number of "herbal" aphrodisiac products sold over-the-counter.
- Common side effects include headaches, flushing, and nasal congestion.
- Serious side effects are rare but may include vision changes or prolonged erections.
- Report any adverse reactions to a healthcare provider immediately.
ERECTILE DYSFUCTION- • Initialdose: 50 mg orally once a day, as needed, 1 hour prior to sexual activity • Maintenance: 25 to 100 mg orally once a day, as needed, 1 hour prior to sexual activity.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 200mg | 120 + 8 Pills | 204.80€ 195.05€ | |
| Viagra Generic | 50mg | 90 + 6 Pills | 107.37€ 102.26€ | |
| Viagra Generic | 25mg | 20 Pills | 37.74€ 35.94€ | |
| Viagra Generic | 25mg | 90 + 6 Pills | 105.03€ 100.03€ | |
| Kamagra Polo | 100mg | 120 + 6 Pills | 327.15€ 311.57€ | |
| Viagra Generic | 25mg | 120 + 6 Pills | 125.56€ 119.58€ | |
| Kamagra Oral Jelly | 100mg | 10 Sachets | 54.55€ 51.95€ | |
| Viagra Generic | 50mg | 10 Pills | 26.87€ 25.59€ | |
| Viagra Generic | 50mg | 270 + 8 Pills | 198.48€ 189.03€ | |
| Kamagra | 100mg | 84 + 6 Pills | 264.44€ 251.85€ | |
| Viagra Generic | 50mg | 360 + 10 Pills | 225.33€ 214.60€ | |
| Kamagra Polo | 100mg | 180 + 8 Pills | 446.52€ 425.26€ | |
| Viagra Generic | 150mg | 120 + 8 Pills | 177.58€ 169.12€ | |
| Kamagra Polo | 100mg | 32 Pills | 125.88€ 119.89€ | |
| Kamagra Soft Tabs | 100mg | 20 Pills | 79.79€ 75.99€ |
HYPERTENSION DOSE- •Initial dose: 5 or 20 mg orally three times a day, 4 to 6 hours apart • -Maximum dose: 20 mg orally three times a day • Injection: • -Initial dose: 2.5 or 10 mg IV bolus three times a day. Nitric oxide (NO) in the corpus cavernosum 50 mg sildenafil price of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation (vasodilation) of the intimal cushions of the helicine arteries.
Before Using
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. This smooth muscle relaxation leads to vasodilation and increased inflow of blood into the spongy tissue of the penis, causing an erection CONTRAINDICATION- • When takingnitric oxide donors, organic nitrites and nitrates, such as glyceryl trinitrate (nitroglycerin), sodium nitroprusside, amyl nitrite. • In men for whom sexual intercourse is inadvisable due to cardiovascular risk factors • Severe hepatic impairment (decreased liver function) • Severe impairment in renal function • Hypotension (low blood pressure) • Recent stroke or heart attack • Hereditary degenerative retinal disorders (including genetic disorders of retinal phosphodiesterases) • Because sildenafilis a vasodilator (although mainly locally), it needs to be used cautiously because it lowers blood pressure.
Society and culture
Referring to the following articles about sildenafil and Viagra can provide you with additional information: For details about other aspects of sildenafil, refer to this article. To learn how sildenafil compares with Viagra, read this article. If you’d like to learn about sildenafil and cost, see this article. For details about your condition, see sildenafil pink pill our hypertension hub. You can also view our men’s health hub and this list of erectile dysfunction and premature ejaculation articles. • Viagra should not be given to patients who are taking nitrates, because nitrates are also a strong vasodilator. The use of both could cause major heart problems. • Also, the use of CYP3A4 or P450 inhibitors (which are the cytochromes responsible for Viagra metabolism), greatly increases the risk of negative side effects. ADVERSE EFFECTS- • HEADACHE •NASAL CONGESTION • DIZZINESS • FLUSHING • FALL IN BP • LOOSE MOTIONS • IMPAIRMENT OF COLOUR DISCRIMINATION PHARMACOKINETICS • Sildenafil citrateis rapidly absorbed after oral administration - Total Bioavailability: 40% • Its pharmacokinetics are dose proportional over the recommended range • Sildenafil citrate is metabolized mainly by hepatic metabolism and excreted mainly in the feces.
2.1 Recommended Dosage in Adults
An eye condition called non-arteritic anterior ischemic optic neuropathy (NAION) may occur in people taking sildenafil. Certain factors can increase your risk of developing NAION during sildenafil treatment. These include previous eye conditions or coronary artery disease. They also include being age 50 years or older or smoking. Before starting sildenafil treatment, be sure to tell your doctor if you have any of these factors.
Pulmonary hypertension
They’ll help determine if the drug is right for you. If you have sickle cell anemia, tell your doctor. You may have an increased risk of vaso-occlusive crisis (VOC) if you have sickle cell anemia and take sildenafil. With VOC, your blood cells block blood flow to your organs, which can be painful. Be sure to talk with your doctor if you have sickle cell anemia. Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4][8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9] It is unclear if it is effective for treating sexual dysfunction in females. [8] It can be taken orally (swallowed by mouth), intravenously (injection into a vein), or through the sublingual route (dissolved under the tongue). [8][10] Onset when taken orally is typically within twenty minutes and lasts for about two hours. Common side effects include headaches, heartburn, and flushed skin.
Further information
In certain cases, your doctor may recommend that you continue taking sildenafil during pregnancy. Sildenafil may pass into breast milk, but it isn’t known how this could affect a child who is breastfed. If you are breastfeeding or planning to breastfeed, talk with your doctor. They can review the risks and benefits of taking sildenafil while breastfeeding. If you are taking sildenafil for erectile dysfunction or pulmonary arterial hypertension, it’s possible to experience side effects.
Revatio Tablets
Most side effects are mild to moderate in severity. If you’re experiencing symptoms of severe side effects while taking sildenafil, talk with your doctor right away. If you’d like to learn more about sildenafil, talk with your doctor or pharmacist. They can help answer any questions you have about side effects from taking the drug. A generic drug and its brand-name version contain the same active ingredient, so they’re expected to have the same side effects. [8] Caution is advised in those with cardiovascular disease. [8] Rare but serious side effects include vision problems, hearing loss, and prolonged erection (priapism) that can lead to damage to the penis. [8] Sildenafil should not be taken by people on nitric oxide donors such as nitroglycerin, as this may result in a serious drop in blood pressure.
- People with certain health conditions should consult their doctor before use.
- Conditions include heart disease, low blood pressure, or kidney/liver issues.
- Adjustments to dosage may be necessary based on health status.
Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis.
Drug Label Information
Sildenafil is contraindicated if you take a GC stimulator, including riociguat (Adempas). This is because these drugs may cause severe low blood pressure. Be sure to tell your doctor if you take this drug. They’ll likely recommend you do not take riociguat with sildenafil. * For more details about this side effect, see the “Sildenafil: Serious side effects” section above.
Sildenafil side effects
It’s unknown whether sildenafil is safe to take while pregnant or breastfeeding. Animal studies* did not show harm to the fetus when the drug was exposed to pregnant animals. However, keep in mind that animal studies don’t always reflect what will happen in humans. If you’re pregnant or can become pregnant, talk with your doctor. They’ll review the risks and benefits with you and advise whether sildenafil treatment is right for you. [8] It requires sexual arousal to work, and does not by itself cause or increase sexual arousal.
- Do not take sildenafil if you are on nitrate medications for chest pain.
- Using both can cause a dangerous drop in blood pressure.
- Always inform your doctor about all medications you are taking.
[8] It also results in dilation of the blood vessels in the lungs. Pfizer originally discovered the medication in 1989 while looking for a treatment for angina. [11] It was approved for medical use in the United States and in the European Union in 1998. [5][8][11][12] In 2023, it was the 151st most commonly prescribed medication in the United States, with more than 3 million prescriptions. [13][14] It is available as a generic medication. [15][16] In the United Kingdom, it is available as a pharmacy medicine. The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete sexual intercourse).